Updated: 10/16/2017

Leuprolide

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Mechanism
  • GnRH analog
    • See female hypothalamic-pituitary axis topic
    • See male hypothalamic-pituitary axis topic
  • Action depends on mode of administration 
    • GnRH antagonist when infusion continuously
    • GnRH agonist when infused in a pulsatile manner
      • is the natural way the body releases GnRH
Indications
  • Infertility (pulsatile)
  • Prostate cancer (continuous)
    • coadministered with flutamide
  • Uterine fibroids
Toxicity
  • Antiandrogen side effects
  • Nausea
  • Vomiting
 

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