Updated: 2/9/2017

Danazol

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Mechanism
  • Partial androgen agonist
    • leads to ovarian steroid synthesis inhibition
Indications
  • Endometriosis
  • Hereditary angioedema
  • Fibrocystic breast disease
Contraindications
  • Pregnancy or breast feeding
  • Genital bleeding
  • Thrombosis or thromboembolic disease
  • Marked hepatic, renal, or cardiac dysfunction
  • Androgen-dependent tumor
Toxicity
  • Weight gain
  • Acne
  • Hirsutism/virilization 
 

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