Snap Shot A 15 year-old male does not demonstrate any signs of puberty. He is short for his age, his testicles show no evidence of enlargement, his testosterone levels are low, and he has a reduced ability to smell. Introduction Type of congenital hypogonadotropic hypogonadism with associated dysfunction of olfactory bulbs Associated with numerous genes (e.g., KAL1, KAL2, etc.) Failed migration of GnRH producing neurons from developping brain including passage to the cribiform plate Lack of GnRH results in login to view 1 more bullet Presentation Cases can represent a range of symptoms and severity Non-reproductive features login to view 5 more bullets Reproductive features login to view 5 more bullets Treatment Hormone replacement login to view 2 more bullets Goals of therapy login to view 3 more bullets