Overview Snapshot A 26-year-old female presents for the evaluation of her headache. Her headache began yesterday, and is on the left side of her skull. It is of throbbing quality, and does not radiate. The pain worsens with physical activity. She reports that sitting in a quiet, dark room helps with her symptoms. She has tried over-the-counter non-steroidal anti-inflammatory (NSAID) medication, which provided no relief. She was then prescribed a medication that she could use as an abortive therapy. Introduction Etiology of migraine headache is not fully understood Data suggests that it may be due primary dysfunction of neurons that leads to headache presentation. login to view 1 more bullet Serotonin and migraine headache login to view 3 more bullets Treatment Mechanism 5-HT1B/1D agonist login to view 5 more bullets Clinical use login to view 6 more bullets Toxicity login to view 2 more bullets