Snapshot A 26-year-old man presents to the emergency department with worsening muscle weakness over the course of 3 days. Prior to developing muscle weakness, he reports acquiring flu-like symptoms, such as a sore throat, myalgias, and headache. Social history is significant for recently emigrating from Pakistan. He does not believe to ever being vaccinated. On physical examination, there is asymmetric proximal muscle weakness of the lower extremities. After extensive workup, his PCR was positive for poliovirus. Introduction Clinical definition login to view 1 more bullet Epidemiology login to view 4 more bullets Pathogenesis login to view 3 more bullets Prognosis login to view 1 more bullet Presentation Symptoms login to view 7 more bullets Physical exam login to view 4 more bullets Studies Labs login to view 2 more bullets Differential Other enteroviruses such as login to view 1 more bullet Guillain-Barre syndrome Acute intermittent porphyria Treatment Conservative login to view 6 more bullets Complications Postpolio syndrome login to view 3 more bullets