MSnapshot A 59-year-old male is brought to the physician by his wife due to "odd behavior." She reports that he would attempt to kiss strangers, or would urinate in public. At times, he would grow distant and show no interest in maintaining a conversation. She has also noticed that he has been frequently binge eating sweets. He does not have insight into his symptoms. On exam, the patient displays disinhibition. There is impairment in executive functioning with intact visuospatial functioning. Introduction Neurodegenerative disorder affecting the frontal and/or temporal lobes login to view 2 more bullets Average onset: 50's There are different variants login to view 2 more bullets Pick bodies login to view 2 more bullets Presentation Behavioral variant (most common) login to view 5 more bullets Primary progressive aphasia login to view 1 more bullet Memory and visuospatial function are relatively preserved (unlike many other forms of dementia) Evaluation Clinical diagnosis Histologic findings login to view 3 more bullets Differential Alzheimer's disease Parkinson's disease Huntington's disease Treatment Symptomatic management Prognosis, Prevention, Complications Prognosis login to view 3 more bullets