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A 75-year-old man is brought to a neurologist by his daughter. She says that her father has had several falls over the last six months. He has also begun having periodic urinary incontinence. She originally attributed these changes to 'old-age.' However, he has now started to become increasingly forgetful. She is concerned that he may have Alzheimer's disease and decided to bring him to the office for evaluation. Physical exam is notable for abnormal gait. Urinalysis is negative for nitrites and leukocyte esterase. CSF analysis shows: Opening pressure: 100 mm H20; Total protein: 20 mg/100mL; WBCs < 5/mm^3. MRI results are shown in Figure A. Which of the following is the most likely mechanism of his disease process?
Beta-amyloid plaque deposition
Scarring of arachnoid granulations
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An 88-year-old man is brought to his primary care physician by his son. The patient has been in excellent health his entire life, but in the last few years appears to have grown steadily confused. He frequently calls his son about things that they have already discussed, forgets where he has placed his keys, and recently the patient's son noticed several unpaid bills on the patient's desk at home. The patient is upset at being "dragged" into see the physician and claims that everything is fine--he is just "getting older". A complete neurologic exam is normal except for significant difficulty with recall tasks. In the course of the medical work-up, you obtain a CT scan and see the findings in figure A. What is the most likely cause of this patient's CT findings?
Blockage of the cerebral aqueduct
Increased CSF production