Overview Snapshot A 63-year-old male is brought to the physician by his wife for the evaluation of a tremor. The tremor is worse at rest, and decreases in severity with purposeful movement. The patient reports to having difficulty with initiating voluntary movement, and his wife states that the patient’s movements have been slow. On exam, there is a “pill-rolling” resting tremor accentuated when the patient is asked to perform mental calculations. On gait testing, there was difficulty with initiating gait, as well as the patient taking short steps when walking forward. (Parkinson's disease) Introduction Main components login to view 5 more bullets Function login to view 1 more bullet Direct pathway in relation to dopamine (DA) login to view 4 more bullets Indirect pathway in relation to DA login to view 5 more bullets Role in disease login to view 12 more bullets