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Updated: Jun 9 2021

Muscarinic Antagonists

  • Therapeutic Actions for Muscarinic Antagonists
      • Therapeutic Actions for Muscarinic Antagonists
      • Drug
      • Organ System
      • Application and Comments
      • Atropine, homatropine, tropicamide
      • Eye and Cardiac
      • Causes mydriasis and cycloplegia
      • Used for ophthalmologic exams
      • Can be used for post-MI bradyarrythmias
      • Benztropine
      • CNS
      • Parkinson's disease
      • Scopolamine
      • CNS
      • Motion sickness
      • Fast onset
      • Ipratropium
      • Respiratory
      • Asthma
      • COPD
      • Tiotropium produces a longer bronchodilator effect
      • Relief of rhinorrhea with common cold, allergic and nonallergic rhinitis
      • Oxybutynin, trospium, glycopyrrolate
      • Genitourinary
      • Reduce urgency in mild cystitis
      • Reduce bladder spasms after urologic surgery
      • Methscopolamine, pirenzepine, propantheline
      • Gastrointestinal
      • Peptic ulcer treatment
  • Atropine
    • Muscarinic antagonist
      • blocks effects of cholinesterase inhibitor poisoning
    • Organ system
      • eye: ↑ pupil dilation and cycloplegia
      • lungs: ↓ secretions
      • GI and GU: ↓ stomach acid secretion, ↓ gut motility, and ↓ urgency in cystitis
    • Toxicity
      • CNS: ↑ body temperature, disorientation, hyperthermia in infants
      • cardiovascular: tachycardia and flushing
      • dermatologic: anhidrosis and urticaria
      • GI and GU: dry mouth, constipation, urinary retention
      • ocular: cycloplegia, acute angle-closure glaucoma, dry eyes
    • Atropine adage: "hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter, the bowel and bladder loser their tone, and the heart runs alone"
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