Therapeutic Actions for Muscarinic Antagonists Therapeutic Actions for Muscarinic Antagonists Drug Organ System Application and Comments Atropine, homatropine, tropicamide Eye and Cardiac Causes mydriasis and cycloplegia Used for ophthalmologic exams Can be used for post-MI bradyarrythmias Benztropine CNS Parkinson's disease Scopolamine CNS Motion sickness Fast onset Ipratropium Respiratory Asthma COPD Tiotropium produces a longer bronchodilator effect Relief of rhinorrhea with common cold, allergic and nonallergic rhinitis Oxybutynin, trospium, glycopyrrolate Genitourinary Reduce urgency in mild cystitis Reduce bladder spasms after urologic surgery Methscopolamine, pirenzepine, propantheline Gastrointestinal Peptic ulcer treatment Atropine Muscarinic antagonist blocks effects of cholinesterase inhibitor poisoning Organ system eye: ↑ pupil dilation and cycloplegia lungs: ↓ secretions GI and GU: ↓ stomach acid secretion, ↓ gut motility, and ↓ urgency in cystitis Toxicity CNS: ↑ body temperature, disorientation, hyperthermia in infants cardiovascular: tachycardia and flushing dermatologic: anhidrosis and urticaria GI and GU: dry mouth, constipation, urinary retention ocular: cycloplegia, acute angle-closure glaucoma, dry eyes Atropine adage: "hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter, the bowel and bladder loser their tone, and the heart runs alone"
QUESTIONS 1 of 5 1 2 3 4 5 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.PH.15.75) A 29-year-old farm hand is brought into the emergency department by his friends because he passed out while working in the field and was not able to be aroused. His friends state they thought he had a stomach bug as he was sweating profusely and had diarrhea and vomiting prior to losing consciousness. On exam, the patient's vitals are: T: 36 deg C, HR: 60 bpm, BP: 100/60 mmHg, RR: 12, SaO2: 99%. Diaphoresis, lacrimation, and increased salivation are appreciated. The patient's eyes are shown in Figure A. Which of the following medications should be administered to this patient? QID: 106850 FIGURES: A Type & Select Correct Answer 1 Pyridostigmine only 2% (6/325) 2 Atropine only 12% (38/325) 3 Pyridostigmine and Physostigmine 6% (19/325) 4 Atropine and Pralidoxime 73% (238/325) 5 Sodium Bicarbonate and Pralidoxime 3% (10/325) M 1 Question Complexity D Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review Tested Concept Review Full Topic (M1.PH.14.44) A 5-year-old boy is brought to the ED with fever and altered mental status. The boy was in his normal state of health until a few hours ago when he began to "not feel good" while on a deep-sea fishing trip as part of his family vacation. By the time that the family made it back to shore, the boy was experiencing blurred vision and confusion. In the ED his vitals were 101.6F, HR160, RR18, and O2 99% on room air. On exam, his skin is dry and flushed, and his abdomen is covered in small, round, stickers similar to that in Figure A. What gastrointestinal and urinary symptoms would you expect in this patient? QID: 101708 FIGURES: A Type & Select Correct Answer 1 Incontinence of stool; urine retention 7% (25/382) 2 Incontinence of stool and urine 12% (46/382) 3 Constipation; urine retention 63% (239/382) 4 Constipation; incontinence of urine 11% (41/382) 5 Incontinence of stool; no urinary symptoms 4% (15/382) M 3 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review Tested Concept Review Full Topic
All Videos (0) Pharmacology | Muscarinic Antagonists Pharmacology - Muscarinic Antagonists Listen Now 11:29 min 9/8/2021 106 plays 5.0 (1)