α-Blockers Nonselective α-Blockers Clinical Applications Toxicity Phenoxybenzamine (irreversible, preferred) Pheochromocytoma High catecholamine states Orthostatic hypotension Reflex tachycardia Phentolamine (reversible) Pheochromocytoma High catecholamine states Orthostatic hypotension Reflex tachycardia Selective α1-blockers (-zosin) Drug Clinical Applications Toxicity Prazosin Hypertension Urinary retention in benign prostatic hyperplasia (tamulosin is the most specific for urinary symptoms) First dose orthostatic hypotension Headache and dizziness Doxazosin Hypertension Urinary retention in benign prostatic hyperplasia (tamulosin is the most specific for urinary symptoms) First dose orthostatic hypotension Headache and dizziness Terazosin Hypertension Urinary retention in benign prostatic hyperplasia (tamulosin is the most specific for urinary symptoms) First dose orthostatic hypotension Headache and dizziness Tamulosin Hypertension Urinary retention in benign prostatic hyperplasia (tamulosin is the most specific for urinary symptoms) First dose orthostatic hypotension Headache and dizziness Selective α2 blockers Drug Clinical Applications Toxicity Mirtazapine Depression Sedation Xerostomia ↑ serum cholesterol ↑ appetite Yohimbine Male erectile dysfunction Hypotension Anxiety α-Blockers + Sympathomimetics effects Epi + α-blocker login to view 4 more bullets Epi + β-blocker login to view 2 more bullets Phenylephrine + α-blocker login to view 2 more bullets