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Updated: Feb 9 2019

Ganglionic Blockers

  • Overview
    • Nicotinic antagonist
      • hexamethonium
        • first drug developed for hypertension treatment
      • mecamylamine
        • CNS penetration therefore can result in sedation, tremor, and choreiform movements
      • trimethaphan
        • short-acting, IV-administered
    • Clinical use
      • block nicotinic receptors at sympathetic and parasympathetic autonomic ganglia
      • have low selectivity and wide array of effects limiting its use
      • used in experimental models to prevent vagal reflex responses to changes in blood pressure such as to prevent reflex bradycardia caused by NE
    • Toxicity
      • severe orthostatic hypotension
      • cycloplegia with loss of accommodation
      • constipation
      • sexual dysfunction: may prevent erection and ejaculation
      • urinary retention in men with prostatic hyperplasia
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