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A 5-year-old boy is brought to the emergency department by his parents for difficulty breathing. He was playing outside in the snow and had progressive onset of wheezing and gasping. His history is notable for eczema and nut allergies. The patient has respirations of 22/min and is leaning forward with his hands on his legs as he is seated on the table. Physical examination is notable for inspiratory and expiratory wheezes on exam. A nebulized medication is started and begins to relieve his breathing difficulties. Which of the following is increased in this patient as a result of this medication?
Protein kinase C
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A 23-year-old woman presents to the emergency department with acute onset of shortness of breath, wheezing, and chest tightness. This is her 4th visit for these symptoms in the last 5 years. She tells you she recently ran out of her normal "controller" medication. Concerned for an asthma exacerbation, you begin therapy with a short-acting beta2-agonist. What is the expected cellular response to your therapy?
Gs protein coupled receptor activates adenylyl cyclase and increases intracellular cAMP
Gs protein coupled receptor activates phospholipase C and increases intracellular calcium
Gq protein coupled receptor activates phospholipase C and increases intracellular calcium
Gq protein coupled receptor activates adenylyl cyclase and increases intracellular cAMP
Gi protein coupled receptor inhibits adenylyl cyclase and decreases cAMP