Introduction Syndromes with associated pathologies involving Addison's disease + para/thyroid disease + GI disease There are 2 types Type I AR inheritance with onset in childhood No HLA relationship Associated conditions Addison's disease primary hypoparathyroidism mucocutaneous candidiasis Type II AD inheritance with onset in young adulthood HLA-Dr3 and Dr4 association Associated conditions Addison's disease Hashimoto's thyroiditis Type I DM