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Updated: Feb 5 2018


  • Overview
    • Synthesis
      • secreted by adrenal zona fasiculata in response to ACTH stimulation
      • CRH is released from the hypothalamus to stimulate ACTH release from the pituitary
      • transported in plasma bound to corticosteroid-binding globulin (CBG)
    • Function
      • maintains blood pressure in response to stress
        • is permissive for catecholamines by upregulating α1 receptors on arterioles
      • ↓ bone formation
      • ↓ immune function by inhibiting:
        • leukotriene and prostaglandin synthesis
        • leukocyte adhesion
        • histamine release
        • eosinophil production
        • IL-2 production
      • ↑ insulin resistence (diabetogenic)
      • ↑ gluconeogenesis, lipolysis, and proteolysis
        • these are the side effects of chronic corticosteroid use (Cushing's syndrome )
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