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Updated: May 29 2017

Hypothalamic / Pituitary Drugs

Images
https://upload.medbullets.com/topic/109041/images/gh pathway.jpg
  • Somatropin
    • Growth hormone (GH) mimetic
    • Mechanism
      • agonist at GH receptors
      • increases production of insulin growth factor-1 (IGF-1)
    • Clinical use
      • GH deficiency
      • increase adult height for children with conditions associated with short stature
        • Turner syndrome
      • wasting in HIV infection
      • short bowel syndrome
    • Toxicity
      • scoliosis
      • edema
      • gynecomastia
      • increased CYP450 activity
  • Octreotide
    • Somatostatin mimetic
    • Mechanism
      • agonist at somatostatin receptors
    • Clinical use
      • acromegaly
      • carcinoid
      • gastrinoma
      • glucagonoma
      • acute esophageal variceal bleed
    • Toxicity
      • GI upset
      • gallstones
      • bradycardia
  • Oxytocin
    • Mechanism
      • agonist at oxytocin receptor
    • Clinical use
      • stimulation of labor
      • uterine contractions
      • control of uterine hemorrhage after delivery
      • stimulate milk letdown
    • Toxicity
      • fetal distress
      • abruptio placentae
      • uterine rupture
  • Desmopressin
    • ADH (vasopressin) mimetic
    • Mechanism
      • agonist at vasopressin V2 receptors
    • Clinical use
      • central (pituitary) diabetes insipidus
      • hemophilia A (factor VIII deficiency)
        • increases availability of factor VIII
      • von Willebrand disease
        • increases release of von Willebrand factor from endothelial cells
    • Toxicity
      • GI upset
      • headache
      • hyponatremia
      • allergic reaction
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