Updated: 9/7/2018

Polyglandular Deficiency Syndrome

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Introduction
  • Syndromes with associated pathologies involving
    • Addison's disease + para/thyroid disease + GI disease
  • There are 2 types
    • Type I
      • AR inheritance with onset in childhood
      • No HLA relationship
      • Associated conditions
        • Addison's disease
        • primary hypoparathyroidism
        • mucocutaneous candidiasis
    • Type II
      • AD inheritance with onset in young adulthood
      • HLA-Dr3 and Dr4 association
      • Associated conditions
        • Addison's disease
        • Hashimoto's thyroiditis
        • Type I DM

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