Updated: 3/16/2020

Signaling Pathways of Endocrine Hormones

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Overview
  • General mechanism
    • releasing hormone (IP3) → pituitary hormone (cAMP) → systemic hormone (steroid)
      • GnRH → FSH/LH → estrogen/testosterone/progesterone
      • TRH → TSH →T3/T4
    • vasoactive hormones
      • cGMP
    • growth factors
      • tyrosine kinase
        • MAP kinase
    • growth hormone, cytokines, hormones
      • receptor tyrosine kinase
        • JAK/STAT

IP3
cAMP
cGMP Tyrosine Kinase (MAP Kinase) Non Receptor Tyrosine Kinase - (JAK/STAT) Steroid
GnRH

FSH

ANP Insulin Prolactin Glucocorticoid
Gastrin
LH NO (EDRF)
IGF-1 Immunomodulators (IL-2,6, and IFN) Estrogen
Oxytocin  ACTH   FGF GH Progesterone
TRH TSH   PDGF  G-CSF Testosterone
ADH (V1) CRH   EGF Erythropoietin  Aldosterone
 Histamine (H1)
hCG  
Thrombopoietin  Vitamin D
 Angiotensin II
PTH  
  T3/T4
  Calcitonin        Cortisol
  Glucagon        
  GHRH (can act via IP3 as well)        
 

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