Overview Synthesis secreted by adrenal zona fasiculata in response to ACTH stimulation CRH is released from the hypothalamus to stimulate ACTH release from the pituitary transported in plasma bound to corticosteroid-binding globulin (CBG) Function maintains blood pressure in response to stress is permissive for catecholamines by upregulating α1 receptors on arterioles ↓ bone formation ↓ immune function by inhibiting: leukotriene and prostaglandin synthesis leukocyte adhesion histamine release eosinophil production IL-2 production ↑ insulin resistence (diabetogenic) ↑ gluconeogenesis, lipolysis, and proteolysis these are the side effects of chronic corticosteroid use (Cushing's syndrome )