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Updated: Dec 15 2016

Atypical Antidepressants

4.6

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(5)

  • Psychiatric Drug Introduction
    • Psychiatric medications can be broken down into the following categories
      • Antidepressants
      • Antipsychotics
      • Bipolar Medications
      • Anxiolytics
  • Overview
    • Buproprion
      • mechanism
        • ↑ NE and dopamine via unknown mechanism
      • other uses
        • smoking cessation
      • toxicity
        • stimulant effects (tachycardia, insomnia)
        • headache
        • seizure in bulimic patients
        • no sexual side effects
    • Mirtazapine
      • mechanism
        • α2 receptor antagonist
          • ↑ release of NE and serotonin
        • 5-HT2 and 5-HT3 receptor antagonist
      • other uses
        • depression + anorexia nervosa
          • due to weight gain side effect
      • toxicity
        • sedation, ↑ appetite, weight gain, dry mouth
    • Amoxapine
      • mechanism
        • antagonism of dopamine receptor
      • toxicity
        • EPS, seizures, cardiotoxicity
    • Maprotiline
      • mechanism
        • blocks NE reuptake
      • toxicity
        • sedation, orthostatic hypotension, seizures, cardiotoxicity
    • Trazodone
      • mechanism
        • primarily inhibits serotonin reuptake
      • other uses
        • causes sedation
          • therefore used for insomnia
        • high doses are needed for antidepressant effects
      • toxicity
        • sedation, nausea, priapism in adolescent boys, orthostatic hypotension
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