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Updated: Jan 11 2022

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

  • Psychiatric Drug Introduction
    • Psychiatric medications can be broken down into the following categories
      • Antidepressants
      • Antipsychotics
      • Bipolar Medications
      • Anxiolytics
  • Overview
    • Drugs
      • venlafaxine
      • duloxetine
    • Mechanism
      • inhibit 5-HT and NE reuptake
        • duloxetine has > blockade on NE
        • serotonin norepinephrine reuptake inhibitors (SNRIs)
          • leads to increased descending inhibition of pain signals
    • Clinical use
      • depression
      • generalized anxiety disorder
        • venlafaxine
      • diabetic peripheral neuropathy
        • duloxetine
    • Toxicity
      • MC is ↑ BP, stimulant effects
        • due to ↑ in NE
      • sedation
      • nausea
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