Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Jun 23 2021

Lithium

Images
https://upload.medbullets.com/topic/114049/images/lithium4.jpg
  • Overview
    • Psychiatric medications can be broken down into the following categories
      • antidepressants
      • antipsychotics
      • mood stabilizers
        • include lithium
      • anxiolytics
  • Mechanism
    • Mood stabilizer
    • Mechanism
      • unknown
      • may be related to inhibition of phosphoinositol recycling in neurons
  • Indications
    • Clinical use
      • mood disorders
        • bipolar disorder
          • for acute treatment of mood episodes and maintenance therapy (prevention of future episodes)
        • major depressive disorder (MDD)
          • adjunctive treatment for some patients who have failed treatment with an antidepressant alone
        • reduces suicide risk in bipolar disorder and MDD
      • SIADH
  • Toxicity and Side Effects
    • Toxicity
      • very narrow therapeutic index
        • requires blood monitoring
        • toxicity may be seen at levels higher than 1.5 mEq/L
        • increased risk in patients who are volume depleted or hyponatremic
        • caution if adding hydrochlorathiazide, NSAID, or ACE-inhibitor
        • loop diuretics do not increase toxicity
      • tremor (coarse tremor indicates likely toxicitiy)
      • sedation
      • ataxia
      • acne
      • edema
      • heart block
      • exclusively excreted by the kidneys (reabsorbed at the proximal convoluted tubule with Na+) and long term use may cause a glomerulopathy
      • hyperparathroidism
      • hypothyroidism
      • polyuria
        • ADH antagonist resulting in nephrogenic diabetes insipidus
        • reason for use in SIADH
      • leukocytosis
      • teratogenesis if given in pregnancy
        • cardiac malformations including Ebstein anomaly in first trimester
Card
1 of 0
Question
1 of 5
Private Note