Updated: 1/14/2021

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

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Psychiatric Drug Introduction
  • Psychiatric medications can be broken down into the following categories
    • Antidepressants
    • Antipsychotics
    • Bipolar Medications
    • Anxiolytics
 
Overview
  • Drugs
    • venlafaxine
    • duloxetine
  • Mechanism
    • inhibit 5-HT and NE reuptake
      • duloxetine has > blockade on NE
      • serotonin norepinephrine reuptake inhibitors (SNRIs)
  • Clinical use
    • depression
    • generalized anxiety disorder
      • venlafaxine
    • diabetic peripheral neuropathy
      • duloxetine 
  • Toxicity
    • MC is ↑ BP, stimulant effects 
      • due to ↑ in NE
    • sedation
    • nausea
 

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