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Updated: Feb 11 2020

Beta-Blockers

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  • β-Blocker Selectivity
      • Nonselective β-Antagonists (β1 = β2)
      • Drug
      • Effect
      • Clinical Applications
      • Toxicity
      • Propranolol, nadolol, timolol
      • Lowers BP and HR
      • Reduces renin secretion
      • Decreases cardiac ouptut and increases peripheral resistance
      • Hypertension
      • Arrhythmias
      • Angina pectoris
      • Migraines
      • Hyperthyroidism
      • Glaucoma (timolol)
      • Bradycardia
      • Fatigue
      • Worsening asthma
      • Vivid dreams
      • β1-Selective Antagonist (β1 > β2)
      • Drug
      • Effect
      • Clinical Applications
      • Toxicity
      • Metoprolol, atenolol, betaxolol
      • Lowers BP and HR
      • Reduces renin secretion
      • Hypertension
      • Arrhythmias
      • Angina pectoris
      • Same toxicity as nonselective ß-antagonists but safer in asthma
      • Esmolol
      • Very rapid onset of action (10 min half-life)
      • Rapid control of supraventricular arrhythmias, BP, and thyrotoxicosis
      • Bradycardia
      • Hypotension
      • Nonselective α- and β-Antagonists (β1 = β2≥ α1 > α2)
      • Drug
      • Effect
      • Clinical Applications
      • Toxicity
      • Labetalol, carvedilol
      • Heart failure
      • Fatigue
      • Partial β-Agonists (β1 = β2 Blockade with Some β-Agonist Activity)
      • Drug
      • Effect
      • Clinical Applications
      • Toxicity
      • Acebutolol, pindolol, carteolol
      • Lowers HR less than the effect on BP
      • Hypertension
      • Arrhythmias
      • Hypotension but less tachycardia than alpha blockers such as phentolamine
  • Mechanism of Action for Clinical Application
      • Mechanism of Action for Clinical Application
      • Clinical Application
      • Mechanism
      • Hypertension
      • ↓ Cardiac output
      • ↓ Renin secretion by blocking β-receptor on JGA cells
      • Angina pectoris
      • ↓ O2 consumption by ↓ heart rate and contractility
      • SVT (propranolol, esmolol)
      • ↓ AV conduction velocity
      • MI
      • ↓ Mortality
      • CHF
      • Slows progression
      • Glaucoma (timolol)
      • ↓ Secretion of aqueous humor
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