Sympathomimetics

(M1.PH.15.6000) In an attempt to create other selective dopamine 1 (D1) agonists, a small pharmaceutical company creates a cell-based chemical screen that involves 3 modified receptors - alpha 1 (A1), beta 1 (B1), and D1. In the presence of D1 stimulation, the cell produces an mRNA that codes for a fluorescent protein; however, if the A1 or B1 receptors are also stimulated at the same time, the cells will degrade the mRNA of the fluorescent protein thereby preventing it from being produced. Which of the following would best serve as a positive control for this experiment?

(M1.PH.15.75) A 75-year-old male arrives by ambulance to the emergency room severely confused. His vitals are T 40 C, HR 120 bpm, BP 80/55 mmHg, RR 25. His wife explains that he injured himself about a week ago while cooking, and several days later his finger became infected, oozing with pus. He ignored her warning to see a doctor and even refused after he developed fever, chills, and severe fatigue yesterday. After being seen by the emergency physician, he was given antibiotics and IV fluids. Following initial resuscitation with IV fluids, he remains hypotensive. The ED physicians place a central venous catheter and begin infusing norepinephrine. Which of the following receptors are activated by norepinephrine?

(M1.PH.15.1) A high-throughput screen to identify new sympathomimetic compounds was developed such that a transgenic line of cells was created that contained the alpha-1 (red), alpha-2 (yellow), beta-1 (green) and beta-2 (blue) receptors. When each of the receptors was activated a different fluorescent protein was expressed and new compounds with different properties could be identified by the fluorescence that they induced. Compound 7583 selectively induced the expression of the blue fluorescent protein. Which of the following known sympathomimetic medications if administered would similarly result in expression of only the blue fluorescent protein?

(M1.PH.13.46) A 58-year-old male is diagnosed with hypertension and started on daily propranolol after failing antihypertensive therapy with other medications. Three months later, his blood pressure appears to be adequately controlled on this therapy. While working in his garden one afternoon, the patient is stung by a wasp and experiences a severe anaphylactic reaction that is subsequently treated with epinephrine. Which of the following effects would be expected upon administration of this epinephrine treatment?

(M1.PH.13.107) An 82-year-old male with congestive heart failure experiences rapid decompensation of his condition, manifesting as worsening dyspnea, edema, and increased fatigue. Labs reveal an increase in his serum creatinine from baseline. As part of the management of this acute change, the patient is given IV dobutamine to alleviate his symptoms. Which of the following effects occur as a result of this therapy?

(M1.PH.13.86) A 24-year-old male being treated for syphilis is given penicillin. Shortly after receiving the first dose the patient becomes dyspneic. Immediate assessment of the patient reveals a heart rate of 150 bpm and a blood pressure of 88/50. The first-line drug used in the treatment of this condition has what effect on alpha and beta autonomic receptors?

(M1.PH.13.77) A 35-year-old male presents to his primary care physician with complaints of seasonal allergies. He has been using intranasal vasoconstrictors several times per day for several weeks. What is a likely sequela of the chronic use of topical nasal decongestants?