Updated: 2/28/2017

Efficacy vs. Potency

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  • Overview
    • Efficacy
      • maximum effect that a drug can produce regardless of dose
    • Potency
      • amount of a drug that is needed to produce a given effect
        • e.g., EC50 is the concentration or dose of drug that causes 50% of maximum effect
      • determined by affinity of drug for receptor and number of receptors available

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(M1.PH.15.75) A laboratory is conducting a study to assess the safety, efficacy, and potency of a group of drugs before allowing the agents to proceed to clinical trials. Figure A shows the dose-response curves for four different drugs from the same class of medications (Drugs A, B, C, & D). Which of the following is true regarding these medications?

QID: 106864
FIGURES:

Drug A has greater efficacy than Drug D

6%

(21/347)

Drug D has greater efficacy than Drug A

1%

(5/347)

Drug A has greater potency than Drug D

82%

(286/347)

Drug D has greater potency than Drug A

0%

(1/347)

All four drugs (A,B,C,D) have equal potencies

5%

(16/347)

M 1 E

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