Snapshot A 25-year-old man presents to the clinic for an annual check-up. He is otherwise healthy and has no significant concerns. Basic laboratory studies demonstrate a sodium level of 129 mg/dL and potassium level of 5.9 mg/dL. A physical examination demonstrates hyperpigmentation of the oral mucosa. Review of systems were positive for generalized fatigue, 5-lbs unintentional weight loss, and some headaches. Introduction Clinical definition login to view 2 more bullets Epidemiology login to view 4 more bullets Pathogenesis login to view 14 more bullets Associated conditions login to view 1 more bullet Presentation Symptoms login to view 7 more bullets Physical exam login to view 5 more bullets Imaging Computed tomography (CT) login to view 1 more bullet Studies Serum cortisol concentration (e.g., morning serum cortisol) login to view 2 more bullets Plasma ACTH concentration login to view 2 more bullets ACTH stimulation test login to view 1 more bullet Plasma aldosterone and renin levels login to view 1 more bullet Chemistry panel login to view 2 more bullets Differential Secondary adrenal insufficiency login to view 3 more bullets Treatment Glucocorticoid replacement therapy login to view 3 more bullets Mineralcorticoid replacement therapy login to view 2 more bullets Androgen replacement therapy login to view 3 more bullets Complications Adrenal crisis login to view 1 more bullet