Snapshot A 3-year-old boy with a history of recurrent pneumonia and chronic diarrhea. His mother states that he has 6-8 four smelling stools per day. PE reveals a low grade fever, scattered rhonchi over both lung fields, crepitant rales at the left lung base and dullness to percussion. Introduction Cystic fibrosis is a genetic disorder leading to excessive, viscous secretions that plug exocrine glands login to view 10 more bullets Affects multiple organ systems with widespread exocrine gland dysfunction login to view 1 more bullet Epidemiology login to view 3 more bullets Presentation Symptoms login to view 17 more bullets Physical exam login to view 9 more bullets Evaluation CXR login to view 4 more bullets Sweat chloride test login to view 3 more bullets Genetic testing login to view 1 more bullet Immunoreactive trypsinogen assay Nasal transepithelial potential difference Pulmonary function testing login to view 4 more bullets Differential Inherited immunodeficiency (SCID, CVID) Primary ciliary dyskinesia Treatment Lifestyle login to view 4 more bullets Pharmacologic login to view 14 more bullets Operative login to view 2 more bullets Prognosis, Prevention, and Complications Prognosis login to view 1 more bullet Prevention login to view 2 more bullets Complications login to view 12 more bullets