Overview Definition non-cancerous growth of tissue due to chronic inflammation Types allergic polyps affects adults with long history of allergies NSAID-associated polyps most commonly affects women with chronic pain conditions (e.g. fibromyalgia) occurs because of ↑ activity of lipoxygenase pathway when cyclooxygenase pathway is blocked ↑ concentrations of bronchoconstricting leukotrienes ↑ concentrations of bronchoconstricting leukotrienes ↑ concentrations of bronchoconstricting leukotrienes classic (Samter's) triad: NSAIDs or aspirin allergy asthma nasal polyp ↑ concentrations of bronchoconstricting leukotrienes cystic fibrosis-associated polyps seen in children if a child has a nasal polyp → get a sweat chloride test to assess for CF hyper viscous mucus leads to chronic nasosinus infections ↑ concentrations of bronchoconstricting leukotrienes