Introduction Renal clearance describes the amount (volume) of plasma that is completely cleared by the kidneys per unit time in other words it reflects the excretion of a substance (e.g., medications) this depends on glomerular filtration tubular reabsorption and secretion clearance decreases gradually with age but may have acute changes due to pathology equation C(x) = (UxV) / Px C(x) = clearance of substance X (mL/min) Ux = urine concentration of substance X (mg/mL) V = urine flow rate (mL/min) Px = plasma concentration of substance X (mg/mL) Clearance ratios C(inulin) C(inulin) = GFR inulin is freely filtered across glomerular capillaries it is neither reabsorbed or secreted amount of inulin filtered equals amount of inulin excreted inulin is a reference substance called a glomerular marker C(x) / C(inulin) > 1.0 C(x) > GFR interpretation there is a net secretion of substance X e.g., para-aminohippuric acid can be used to determine renal plasma flow C(x) / C(inulin) < 1.0 C(x) < GFR interpretation there is a net reabsorption of subtance X e.g., glucose
QUESTIONS 1 of 4 1 2 3 4 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.RL.17.4695) A 45-year-old gentleman with a history of poorly controlled diabetes mellitus is referred to a nephrologist for evaluation of the possibility of early stage kidney failure. Upon evaluation, the nephrologist decides to assess the patient's renal plasma flow by performing a laboratory test. Which of the following substances would be the best for estimating this value? QID: 107948 Type & Select Correct Answer 1 Creatinine 21% (80/388) 2 Inulin 21% (83/388) 3 Glucose 1% (3/388) 4 Para-aminohippurate (PAH) 53% (207/388) 5 Urea 2% (9/388) M 1 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
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