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Review Question - QID 212790

Renal Clearance Introduction Renal clearance QID: 212790 (M1.OMB.19.1)
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QID 212790 (Type "212790" in App Search)
An 81-year-old man presents to his primary care physician for his yearly exam. His past medical history is significant for osteopenia, nephrolithiasis, and hypertension. His family history is significant for relatives who had early onset kidney failure. He takes occasional acetaminophen and supplemental calcium/vitamin D. He is physically active with a normal body mass index (BMI) and has no current concerns. Review of his laboratory results today were compared with those from 15 years ago with the following findings:

Results today:
Serum creatinine concentration: 1.1 mg/dL
Urine creatinine concentration: 100 mg/dL
Urine volume: 1000 mL/day

Results 15 years ago:
Serum creatinine concentration: 1.1 mg/dL
Urine creatinine concentration: 120 mg/dL
Urine volume: 1000 mL/day

Which is the most likely cause of these changes in his creatinine clearance?
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