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Updated: Mar 31 2023


  • Introduction
    • Filtration fraction (FF) represents the ratio between glomerular filtration rate (GFR) and renal plasma flow (RPF)
      • this in turn represents which fraction of RPF becomes filtered via the glomerular capillaries
        • the normal filtration fraction is ~20% and thus implies that 80% of the RPF is not filtered
          • the unfiltered RPF will then be part of the peritubular capillary blood flow after entering the efferent arteriole
      • Filtration fraction (FF) = GFR / RPF
      • Filtered load = GFR x plasma concentration
    • Renal plasma flow (RPF)
      • can be determined by using clearance of para-aminohippuric acid (PAH)
        • RPF = [U(PAH) x V] / [RA(PAH) - RV (PAH)]
          • U(PAH) = urine concentration of PAH (mg/mL)
          • V = urine flow rate (mL/min)
          • RA(PAH) = renal artery concentration of PAH (mg/mL)
          • RV(PAH) = renal vein concentration of PAH (mg/mL)
      • determining the RPF will allow you to determine the renal blood flow (RBF)
        • RBF = RPF / (1 - hematocrit)
      • Changes in Starling Force and Its Effect On RPF, GFR, and FF
      • Condition
      • RPF
      • GFR
      • FF (GFR/RPF)
      • Afferent arteriole constriction
      • Unchanged
      • Efferent arteriole constriction
      • ↑ plasma protein concentration
      • Unchanged
      • ↓ plasma protein concentration
      • Unchanged
      • Ureter constriction
      • Unchanged
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