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0.5 mg/mL
12%
19/161
1 mg/mL
15%
24/161
2 mg/mL
39%
62/161
3 mg/mL
7%
12/161
There is insufficient information available to estimate the plasma concentration of Compound X
17%
28/161
Select Answer to see Preferred Response
Plasma Concentration of Compound X is calculated to be 2 mg/mL. See Illustration A below for complete step-wise solution. Baumgarten et al. discuss the use of serum creatinine levels in order to estimate the glomerular filtration rate (GFR). For patients with chronic kidney disease (CKD), staging of their condition is based on the calculated estimated GFR. In turn, this staging of CKD guides prognosis, evaluation, and management of the patient. Stevens et al. explain some of the pitfalls associated with estimating GFR via creatinine. Most labs report an estimated GFR value based on the serum creatinine level. For the majority of instances, this estimate is acceptable for clinical decision-making. However, these estimates may be more inaccurate in some patients, particularly in non-steady state scenarios and in patients with very different non-GFR determinants from those patients in whom the estimating equation was initially developed. A measured GFR (as opposed to an estimated value) is extremely important as a confirmatory test if you suspect an estimated GFR is inaccurate. Illustration A shows the step-wise approach to solving this problem. Illustration B depicts a schematic of renal physiology, including a representation of Equation 1 featured in Illustration A. Incorrect answers: Answers 1,2,4: The plasma concentration, as calculated in Illustration A, is 2 mg/mL. Answer 5: As demonstrated in illustration A, there is sufficient information to plug the provided values into the two equations and solve for the plasma concentration.
3.9
(11)
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