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Updated: Mar 27 2018

Glomerular Filtration Barrier

  • Overview
  • Introduction
    • Glomerular filtration barrier
      • a membrane that selectively allows the passage of molecules based on size and charge
      • the glomerular filtration barrier is composed of
        • fenestrated capillary endothelium
        • basement membrane
          • contains heparan sulfate, a negatively charge glycoprotein that repels negatively charged molecules (e.g., proteins such as albumin)
          • also contains type IV collagen
            • clinical correlate
              • Goodpasture's syndrome
                • an autoimmune disorder that consists of antibodies against α3 chain of type IV collagen of the basement membrane of both the glomerulus and alveoli
                  • this is categorized as a type II hypersensitivity reaction
        • epithelial layer
          • contains podocyte foot processes
            • clinical correlate
              • minimal change disease
                • a type of nephrotic syndrome that is categorized by effacement of the podocyte foot processes appreciated on
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