Sulfalazine Mechanism sulfapyridine + 5-aminosalicylic acid sulfapyridine is an antibiotic that surpresses B-cell function 5-ASA is a COX inhibitor joined molecule is split by colonic bacteria Clinical use ulcerative colitis Crohn's disease Toxicity malaise/nausea sulfa toxicity reversible oligospermia hemolysis in G6PD deficiency References