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Updated: May 30 2017

Bismuth / Sucralfate

Gastrointestinal Drug Introduction
  • Gastrointestinal medications can be broken down into the following categores
    • antidiarrheals
    • antiemetics
    • H2 antagonists
    • proton pump inhibitors
    • other antiulcer medications
    • laxitives
 
Sucralfate
  • Mechanism
    • provides physical protection to ulcer base
      • requires low pH to activate into a paste consistancy that adhears to the mucosal wall
      • action may be inhibited by antacids
  • Clinical use
    • ↑ ulcer healing
    • ↓ ulcer recurrance
Bismuth subsalicylate
  • Mechanism
    • similar to sucralfate
  • Clinical use
    • ↑ ulcer healing
    • traveler's diarrhea
    • triple therapy of H. pylori ulcers (BMT regimen)
      • Bismuth
      • Metronidazole
      • Tetracycline (Amoxicillin)
        • may also use PPI
  • Toxicity
    • harmless black coloring of stool
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