Gastrointestinal Drug Introduction Gastrointestinal medications can be broken down into the following categores antidiarrheals antiemetics H2 antagonists proton pump inhibitors other antiulcer medications laxitives Sucralfate Mechanism provides physical protection to ulcer base requires low pH to activate into a paste consistancy that adhears to the mucosal wall action may be inhibited by antacids Clinical use ↑ ulcer healing ↓ ulcer recurrance Bismuth subsalicylate Mechanism similar to sucralfate Clinical use ↑ ulcer healing traveler's diarrhea triple therapy of H. pylori ulcers (BMT regimen) Bismuth Metronidazole Tetracycline (Amoxicillin) may also use PPI Toxicity harmless black coloring of stool