Introduction Most common vascular abnormality of the GI tract Second leading cause of lower GI bleeding in patients older than 60 years diverticulosis is #1 most common cause of lower GI bleeding in patients with chronic renal failure or end-stage renal disease A degenerative lesion of previously healthy blood vessels 77% of angiodysplasias are located in the cecum and ascending colon 15% are located in the jejunum and ileum associated with aortic stenosis Presentation Symptoms hematochezia (60%) melena (26%) hematemesis frequently is observed in patients with angiodysplasia of the upper GI tract Physical exam hemocult positive stool (47%) Evaluation Colonoscopy or angiography Capsule endoscopy used to assess small intestine Microcytic hypochromic anemia iron deficiency anemia (51%) reflecting iron deficiency observed in 10-15% of cases Treatment A conservative approach to patients who are hemodynamically stable is recommended most bleeding angiodysplasias will cease spontaneously cautery of the AVM can be done in refractory cases