Updated: 3/30/2019

Pancreas and Spleen Embryology

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 This illustrations shows the embryological development of the pancreas. The ventral bud rotates dorsally to meet the dorsal bud, and then the two fuse to form the adult pancreas. 
Pancreas
  • Normal embryology
    • outgrowth of foregut endoderm induced by notochord
      • ventral pancreatic bud forms
        • pancreatic head
        • uncinate process
        • main pancreatic duct
      • dorsal pancreatic bud forms
        • body
        • tail
        • isthmus
        • accessory pancreatic duct
      • ventral bud rotates dorsally to fuse with dorsal bud
Spleen
  • Mesodermal in origin
  • Derived from dorsal mesentery
  • Supplied by splenic artery which is a branch of the celiac artery
    • travels within the splenorenal ligament
Pathology
  • Annular pancreas
    • ventral and dorsal buds fuse both dorsally and ventrally, encircling the 2nd part of duodenum
    • may cause duodenal narrowing
    • emesis is usually nonbilious 
  • Pancreas divisum
    • ventral and dorsal buds fail to fuse, forming two separate pancreatic systems
    • prone to pancreatitis
  • Accessory pancreatic duct
    • dorsal pancreatic duct opens into duodenum

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