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A 1-month-old boy is brought to the emergency department by his parents for recent episodes of non-bilious projectile vomiting and refusal to eat. The boy had no problem with passing meconium or eating at birth; he only started having these episodes at 3 weeks old. Further history reveals that the patient is a first born male and that the boy’s mother was treated with erythromycin for an infection late in the third trimester. Physical exam reveals a palpable mass in the epigastrum. Which of the following mechanisms is likely responsible for this patient’s disorder?
Defect of lumen recanalization
Hypertrophy of smooth muscle
Intestinal vascular accident
Neural crest cell migration failure
Pancreatic fusion abnormality
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A 2-week-old boy has developed bilious vomiting. He was born via cesarean section at term. On physical exam, his pulse is 140/min, blood pressure is 80/50 mmHg, and respirations are 40/min. His abdomen appears distended and appears diffusely tender to palpation. Abdominal imaging is obtained (Figures A). Which of the following describes the mechanism that caused this child's disorder?
Ischemia-reperfusion injury in premature neonate
Telescoping segment of bowel
Abnormal rotation of the midgut
Hypertrophy of the pylorus
Partial absence of ganglion cells in large intestine
A 1-week-old male is brought by his mother to their pediatrician's office with complaints of a 3 day history of feeding intolerance and frequent bilious vomiting. An upper GI contrast radiograph is obtained (Figure A) and shows obstruction of the 3rd part of the duodenum with displacement of the duodenojejunal junction to the right of midline. Which of the following mechanisms is responsible for this infant's condition?
Failure to recanalize the lumen of the duodenum
Hypertrophy of the muscularis externa at the pylorus
Failed fusion of lateral body folds
Failed fusion of the dorsal and ventral pancreatic buds