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Tamoxifen
  • Mechanism
    • estrogen antagonist in breast
    • estrogen agonist in endometrium, bone
  • Indications
    • estrogen-receptor positive breast cancer
  • Toxicity
    • ↑ risk of DVTs
    • ↑ risk of endometrial cancer
      • secondary to agonist activity
    • induces menopause
      • hot flashes
    • prevents osteoporosis
      • secondary to agonist action in bone
Raloxifene
  • Mechanism
    • estrogen antagonist in breast, endometrium
    • partial agonist in bone
  • Indications
    • osteoporosis in menopausal women
  • Toxicity
    • ↑ risk of DVTs
    • induces menopause
      • hot flashes
    • NO ↑ risk of endometrial cancer
      • secondary to antagonist activity in endometrium
 

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