Snapshot A 36-year-old woman presents to the emergency department with severe and colicky left flank pain that radiates to the left groin. She reports increased urinary frequency and urgency. She is sexually active with multiple men and uses condoms inconsistently. On physical exam, there is left-sided costovertebral angle tenderness and lower abdominal tenderness. Introduction Clinical definition calculi (stones) affecting the kidneys; however, these stones can also affect the ureter Epidemiology prevalence 12% in men and 7% in women risk factors hyperparathyroidism hypocitraturia sarcoidosis hyperoxaluria renal tubular acidosis type I nephrocalcinosis cystic fibrosis hyperuricosuria indwelling catheter urinary tract infections malabsorption (e,g., Crohn disease) horseshoe kidney obesity low fluid intake gout medications e.g., allopurinol, indinavir, acetazolamide, and topiramate Pathogenesis substance precipitation affecting the kidney and ureter e,g., hypercalciuria and low urine volume forms calcium cystals Prognosis small stones are more likely to spontaneously pass Nephrolithiasis Stones Stone Type Etiology Imaging Findings Stone Shape Treatment Calcium Calcium oxalate stones (most common) hypercalciuria hypocitraturia ethylene glycol (antifreeze) vitamin C abuse crohn disease Calcium phosphate in states of urine alkalinization e.g., type I renal tubular acidosis Radiography radiopaque Computerized tomography radiopaque Envelope or dumbbell shape calcium oxalate Wedge-shaped prism calcium phosphate Hydrochlorothiazide Citrate Low-sodium diet Cystine Impaired cystine reabsorption in the proximal convoluted tubule this results in cystinuria also results in decreased reabsorption of ornithine, lysine, and arginine Precipitates in acidic urine Diagnosis cyanide-nitroprusside test Radiography radiolucent Computerized tomography visible at times Hexagonal Dietary modification low sodium Urine alkalinization Chelating agents in refractory cases Struvite (magnesium ammonium phosphate) Urease-positive organisms such as Proteus mirabilis Staphylococcus saphrophryticus Klebsiella Urease-positive organisms subesequently alkalinizes the urine this causes struvite stones due to precipitation Radiography radiopaque Computerized tomography radiopaque Can result in a staghorn calculi Coffin lid Removal of underlying infection Surgical removal of the stone Uric acid Hyperuricemia e.g., states of increased cell turnover and gout Precipitates in acidic urine Radiography radiolucent Computerized tomography minimally visible Rhomboid/rosette Urine alkalinization Allopurinol Adequate hydration prior to chemotherapy treatment Presentation Symptoms colicky flank pain pain may radiate to the groin or lower abdomen dysuria urgency and frequency Physical exam low abdominal tenderness costovertebral angle (CVA) tenderness Imaging Renal ultrasound indication in patients who are pregnant and children who are suspected to have nephrolithiasis modality abdomen and pelvis to visualize the kidney and bladder Non-contrast computerized tomography (CT) indication preferred imaging for most adults presenting with signs and symptoms concerning for nephrolithiasis modality abdomen and pelvis Studies Labs serum creatinine, uric acid, and ionized calcium should be obtained urine studies urinalysis/dipstick in order to check for red and white blood cells, nitrites, and urine pH urine culture stone composition analysis perform in patients who developed their first stone straining the urine Diagnostic criteria based on clinical presentation and confirmed by imaging Differential Urinary tract infections Acute pyelonephritis Groin hernia Complications Ureteral obstruction Ureteral stricture Urinary tract infection Renal deterioration