Updated: 2/27/2019

Cryptogenic Organizing Pneumonia

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Introduction
  • Definition
    • inflammation and fibrosis of the small airways (bronchioles) 
    • manifestation of chronic rejection in lung transplant  (and allogenic bone marrow transplant)
      • involves small bronchioles 
      • obstructive pattern on PFTs (reduced FEV1/ FVC)
    • major problem in lung transplant patients 
      • vasculature is relatively unaffected unlike other examples of chronic organ rejection
        • e.g. kidney
    • Other etiologies
      • viral infections
      • collagen vascular diseases
      • toxic fumes
      • rheumatoid arthritis
  • Pathophysiology
    • lymphocytic inflammation of bronchiolar wall
    • damage replaced by fibrous tissue
    • progressive reduction in diameter of small airway lumens

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