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Updated: Feb 27 2019

Cryptogenic Organizing Pneumonia

Images
https://upload.medbullets.com/topic/117061/images/bronchiolitis_obliterans.jpg
  • Introduction
    • Definition
      • inflammation and fibrosis of the small airways (bronchioles)
      • manifestation of chronic rejection in lung transplant (and allogenic bone marrow transplant)
        • involves small bronchioles
        • obstructive pattern on PFTs (reduced FEV1/ FVC)
      • major problem in lung transplant patients
        • vasculature is relatively unaffected unlike other examples of chronic organ rejection
          • e.g. kidney
      • Other etiologies
        • viral infections
        • collagen vascular diseases
        • toxic fumes
        • rheumatoid arthritis
    • Pathophysiology
      • lymphocytic inflammation of bronchiolar wall
      • damage replaced by fibrous tissue
      • progressive reduction in diameter of small airway lumens
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