Overview Guaifenesin (Robitussin) removes excess sputum does not suppress cough reflex must use large doses N-acetylcysteine mucolytic cleaves disulfide bridges between mucus glycoproteins loosens mucus plugs in CF patients also used as an antidote for acetaminophen overdose Dextromethorphan over the counter cough suppressant side effect of constipation overdose can lead to hallucinations
QUESTIONS 1 of 4 1 2 3 4 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.PL.15.75) After receiving a positive newborn screening result, a 2-week-old male infant is brought to the pediatrician for a diagnostic sweat test. The results demonstrated chloride levels of 65 mmol/L (nl < 29 mmol/L). Subsequent DNA sequencing revealed a 3 base pair deletion in a transmembrane cAMP-activated ion channel known to result in protein instability and early degradation. The physician discusses with the parents that the infant will develop respiratory infections due to improper mucus clearance and reviews various mucolytic agents, such as one that cleaves disulfide bonds between mucus glycoproteins thereby loosening the mucus plug. This mucolytic can also be used as a treatment for which of the following overdoses? Tested Concept QID: 106837 Type & Select Correct Answer 1 Opioids 7% (8/118) 2 Acetaminophen 64% (76/118) 3 Cyanide 11% (13/118) 4 Benzodiazepines 2% (2/118) 5 Salicylates 12% (14/118) M 1 Question Complexity D Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review tested concept (M1.PL.13.9) A 5-year-old Caucasian boy presents with a productive cough that yields thick sputum. His past medical history is significant for three prior pulmonary infections, two of which cultured S. aureus and one that was positive for Pseudomonas. Chest radiograph today is shown in Figure A. Which of the following pharmacologic agents act most directly to counteract the defective physiologic process in these patients? Tested Concept QID: 100812 FIGURES: A Type & Select Correct Answer 1 Ipratroprium 7% (5/67) 2 Beclomethasone 15% (10/67) 3 Albuterol 7% (5/67) 4 Zileuton 10% (7/67) 5 N-acetylcysteine 58% (39/67) M 3 Question Complexity E Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review tested concept