Updated: 10/24/2018

H1 Blockers

0%
Topic
Review Topic
0
0
N/A
N/A
Questions
4
0
0
0%
0%
Evidence
1
0
0
Topic
  • Overview
    • Mechanism
      • reversible inhibition of H1 histamine receptors
  • 1st generation
    • Drugs
      • diphenhydramine (Benadryl)
      • dimenhydrinate (Dramamine)
      • chlorpheniramine
      • hydroxyzine
      • promethazine
        • abused as a recreational drug ("purple drank" or "sizzurp")
    • Clinical uses
      • allergy
      • motion sickness
      • sleep aid
    • Toxicity
      • antimuscarinic
      • anti-α-adrenergic
      • sedation (lipophilic and thus crosses brain barrier)
  • 2nd generation
    • Drugs
      • loratadine (Claritin)
      • fexofenadine (Allegra)
      • cetirizine (Zyrtec)
      • desloratadine
    • Clinical uses
      • allergy
    • Toxicity
      • decreased entry into CNS (lipophobic) makes this generation far less sedating

Please rate this review topic.

You have never rated this topic.

Thank you. You can rate this topic again in 12 months.

Flashcards (0)
Cards
1 of 0
Questions (4)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK

(M1.PL.14.1) A 3-year-old girl swallowed a handful of pills after her grandmother dropped the bottle on the ground this afternoon. She presents to the ER in a very drowsy but agitated state. She is clutching her abdomen, as if in pain, her skin is dry and flushed, and she does not know her name or where she is. Her pupils are dilated. Her grandmother reports that she has not urinated in several hours. The grandmother's medical history is significant for allergic rhinitis and osteoarthritis, both of which are treated with over the counter medications. What is the appropriate treatment for this child?

QID: 105611

Atropine

18%

(20/112)

N-acetylcysteine

24%

(27/112)

Naloxone

12%

(13/112)

Physostigmine

37%

(41/112)

Deferoxamine

4%

(5/112)

M 3 E

Select Answer to see Preferred Response

Evidence (1)
VIDEOS & PODCASTS (1)
EXPERT COMMENTS (7)
Private Note