Overview Mechanism reversible inhibition of H1 histamine receptors 1st generation Drugs diphenhydramine (Benadryl) dimenhydrinate (Dramamine) chlorpheniramine hydroxyzine promethazine abused as a recreational drug ("purple drank" or "sizzurp") Clinical uses allergy motion sickness sleep aid Toxicity antimuscarinic anti-α-adrenergic sedation (lipophilic and thus crosses brain barrier) 2nd generation Drugs loratadine (Claritin) fexofenadine (Allegra) cetirizine (Zyrtec) desloratadine Clinical uses allergy Toxicity decreased entry into CNS (lipophobic) makes this generation far less sedating
QUESTIONS 1 of 4 1 2 3 4 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M1.PL.14.1) A 3-year-old girl swallowed a handful of pills after her grandmother dropped the bottle on the ground this afternoon. She presents to the ER in a very drowsy but agitated state. She is clutching her abdomen, as if in pain, her skin is dry and flushed, and she does not know her name or where she is. Her pupils are dilated. Her grandmother reports that she has not urinated in several hours. The grandmother's medical history is significant for allergic rhinitis and osteoarthritis, both of which are treated with over the counter medications. What is the appropriate treatment for this child? Tested Concept QID: 105611 Type & Select Correct Answer 1 Atropine 12% (7/58) 2 N-acetylcysteine 29% (17/58) 3 Naloxone 7% (4/58) 4 Physostigmine 41% (24/58) 5 Deferoxamine 2% (1/58) M 3 Question Complexity D Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review tested concept