Overview ~15.0 g/dL hemoglobin in blood most oxygen in blood is attached to hemoglobin > 5.0 g/dL deoxyhemoglobin in blood → cyanosis ↓ hemoglobin → ↓ O2 content ↓ hemoglobin does not change O2 saturation, arterial PO2 chronic lung disease → ↓ arterial PO2 physiologic shunt → ↓ O2 extraction ratio 1.0 g hemoglobin can bind 1.34 mL O2 O2 binding capacity = (15.0 g hemoglobin / dL blood) x (1.34 mL O2 / 1.0 g hemoglobin) = 20.1 mL O2 / dL O2 content = (O2 binding capacity) x (% saturation) + dissolved O2 dissolved oxygen can usually be ignored because it is multiplied by 0.003 to correct for units (mL O2 / mmHg / dL), and becomes negligible O2 delivery = (cardiac output) x (O2 content)
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