Snapshot An 18-year-old African American man with a history of sickle cell trait presents with 1 week of painless gross hematuria. On review of systems, he endorses a 10 pound weight loss within the past 2 months. Physical exam reveals a left-sided abdominal mass. His serum creatinine is found to be elevated. He is sent to the emergency room for urgent CT imaging. (Renal medullary carcinoma secondary to sickle cell trait). Introduction Clinical definition login to view 3 more bullets Epidemiology login to view 11 more bullets Pathogenesis login to view 4 more bullets Prognosis login to view 6 more bullets Presentation Symptoms login to view 10 more bullets Physical exam login to view 6 more bullets Imaging Ultrasound login to view 6 more bullets CT login to view 4 more bullets Studies Labs login to view 5 more bullets Urinalysis login to view 3 more bullets Hemoglobin electrophoresis Diagnostic criteria Differential Nephrolithiasis login to view 1 more bullet Treatment Conservative login to view 4 more bullets Medical login to view 3 more bullets Operative login to view 3 more bullets Complications End-stage renal disease Renal medullary carcinoma with metastases