Introduction The kidneys play an important role in regulating the body's acid-base status via login to view 41 more bullets Acid-Base Disorders Acidosis results in acidemia due to an increased serum H+ (decreased pH) Alkalosis results in alkalemia due to a decreased serum H+ (increased pH) These acid base disorders may be due to primary disturbances in HCO3− (metabolic) or arterial CO2 (PCO2) (respiratory) login to view 2 more bullets Metabolic acidosis login to view 2 more bullets Metabolic alkalosis login to view 1 more bullet Respiratory acidosis login to view 2 more bullets Respiratory alkalosis login to view 2 more bullets Winter's formula login to view 4 more bullets Acid-Base Disorders Acid-Base Disorder pH PCO2 [HCO3-] Compensatory Response Metabolic acidosis ↓ ↓ ↓ (primary disturbance) Hyperventilation Metabolic alkalosis ↑ ↑ ↑ (primary disturbance) Hypoventilation Respiratory acidosis ↓ ↑ (primary disturbance) ↑ ↑ renal HCO3- reabsorption Respiratory alkalosis ↑ ↓ (primary disturbance) ↓ ↓ renal HCO3- reabsorption