Updated: 3/27/2018

Glomerular Filtration Barrier

0%
Topic
Review Topic
0
0
N/A
N/A
Questions
1 1
0
0
Overview
 

 
Introduction
  • Glomerular filtration barrier
    • a membrane that selectively allows the passage of molecules based on size and charge
    • the glomerular filtration barrier is composed of
      • fenestrated capillary endothelium
      • basement membrane
        • contains heparan sulfate, a negatively charge glycoprotein that repels negatively charged molecules (e.g., proteins such as albumin)
        • also contains type IV collagen
          • clinical correlate
            • Goodpasture's syndrome
              • an autoimmune disorder that consists of antibodies against α3 chain of type IV collagen of the basement membrane of both the glomerulus and alveoli
                • this is categorized as a type II hypersensitivity reaction
      • epithelial layer
        • contains podocyte foot processes
          • clinical correlate
            • minimal change disease
              • a type of nephrotic syndrome that is categorized by effacement of the podocyte foot processes appreciated on 
 

Please rate topic.

Average 4.7 of 12 Ratings

Questions (1)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Topic COMMENTS (6)
Private Note