Please confirm topic selection

Are you sure you want to trigger topic in your Anconeus AI algorithm?

Please confirm action

You are done for today with this topic.

Would you like to start learning session with this topic items scheduled for future?

Updated: Apr 2 2018

Antigen Processing and Presentation

  • Introduction
    • Antigens must be presented to the adaptive immune system so that
      • specialized antigen presenting cells (APCs) can activate the immune system
      • killer T-cells can monitor the intracellular contents of all cells
      • helper T-cells can be alerted to both intracellular and extracellular antigens
    • Two types of antigens are processed by cells for presentation on the cell surface
      • endogenous antigens are proteins produced by the cell
      • exogenous antigens are proteins that are taken up by the cell
    • Both types are linked to major histocompatability complexes (MHC) during processing so that
      • they can be stably exported to the cell surface
      • they can be recognized specifically by T-cells
    • Antigens are presented to two distinct cell populations including
      • CD4+ helper T-cells that
        • recognize antigens loaded onto MHC class II
      • CD8+ killer T-cells that
        • recognize antigens loaded onto MHC class I
  • Antigen Processing
    • Antigens must undergo a number of transformations before being presented including
      • degradation of proteins into component peptides
      • translocation of the peptides into the appropriate compartment
      • loading of the peptides onto MHC proteins
    • The processing of antigens must therefore preserve information about
      • the location from where the antigen originated
      • the type of response that is required
      • Antigen Processing Pathways
      • Feature
      • MHC Class I
      • MHC Class II
      • Function
      • Allow for sampling of intracellular antigens
      • Signal that a cell is infected or abnormal
      • Allow for sampling of extracellular antigens
      • Signal that pathogens are within the host
      • Target cell
      • CD8+ killer T-cells
      • Rule of 8: (MHC) 1 x (CD) 8 = 8
      • CD4+ helper T-cells
      • Rule of 8: (MHC) 2 x (CD) 4 = 8
      • Antigens
      • Endogenous antigens
      • Exogenous antigens
      • Degradation
      • By proteosomes in the cytosol
      • By proteases in the phagosome
      • Translocation
      • Into ER by TAP proteins
      • Into endosomes after phagocytosis
      • Loading
      • Directly bind to MHC I
      • Bind to MHC II after release of invariant chain
      • Defect
      • Absent CD8+ activity
      • Absent CD4+ activity
  • Antigen Presentation
    • After processing, antigenic peptides are loaded on surface MHC proteins where
      • T-cell receptors can bind specifically to the peptide
      • CD4 and CD8 can bind specifically to the corresponding MHC
      • Integrins can bind APCs
    • Together, this set of interactions allows for
      • specific detection of antigens
      • activation of T-cells
1 of 0
1 of 2
Private Note

Attach Treatment Poll
Treatment poll is required to gain more useful feedback from members.
Please enter Question Text
Please enter at least 2 unique options
Please enter at least 2 unique options
Please enter at least 2 unique options