Introduction There are two primary lymphoid organs in humans including the bone marrow the site of development for B-cells thymus the site of development for T-cells They serve as the site of adaptive immune cell maturation steps such as replication of an immature progenitor cell population recombination of VDJ regions to generate adaptive immune cell receptors positive selection to remove cells with defective surface receptors negative selection to remove cells that are reactive against self-antigens Abnormalities in primary lymphoid tissue can result in immunocompromise due to failure of adaptive immune cell development autoimmunity due to failure of central tolerance mechanisms (negative selection) Bone Marrow Bone marrow is the site of pluripotent hematopoietic stem cells that can differentiate into many different lineages of which the two relevant to immunity are the lymphoid lineage, which login to view 5 more bullets the myeloid lineage which login to view 9 more bullets Bone marrow also serves as the site of B-cell maturation where the B-cell receptor is recombined immature B-cells undergo both positive and negative selection Thymus This photomicrograph shows a hassall corpuscle, which is a characteristic feature of the inner medulla of the thymus and is composed of epithelial reticular cells. The thymus is a primary lymphoid organ that is located in the anterosuperior mediastinum derived from the third pharyngeal pouch bilobed in structure with a dense cortex and a pale medulla the site of Hassall corpusles containing epithelial reticular cells The thymus serves as the site of T-cell maturation where the T-cell receptor is recombined immature T-cells undergo both positive and negative selection The thymus is composed of several regions including an outer cortex region with immature T-cells a network of epithelial cells, dendritic cells, and macrophages a corticomedullary region that serves as the site for positive selection of T-cell receptor development negative selection against autoimmune T-cells an inner medullary region containing mature T-cells epithelial reticular cells Hassall's corpuscles Abnormalities Abnormal development of primary lymphoid organs can lead to immunodeficiency syndromes such as severe combined immunodeficiency (SCID) thymic aplasia (DiGeorge syndrome) which login to view 8 more bullets autoimmunity syndromes such as myasthenia gravis associated with login to view 1 more bullet generalized autoimmunity due to login to view 1 more bullet