Overview Cell-mediated immunity is the result of cooperation between innate and adaptive immunity to login to view 3 more bullets Cells involved in immunity can be divided into login to view 8 more bullets Cell-mediated immunity can result from login to view 3 more bullets Important Cytokines in Cellular Immunity Cytokines are key coordinators of the cellular immune response by promoting login to view 4 more bullets Cytokines can be secreted by a variety of cells including login to view 3 more bullets Important Cytokines in Cellular Immunity Cytokine Function Secreted by Interleukin-1 Causes fever and acute inflammation Activates endothelial expression of adhesion molecules Macrophages Interleukin-2 Stimulates growth and survival of T-cells and NK cells All T-cells Interleukin-3 Stimulates the growth and differentiation of bone marrow cells All T-cells Interleukin-4 Induces differentiation of helper T-cells into Th2 subtype cells Promotes growth of B-cells and enhances class switching to IgG and IgE Th2 cells Interleukin-5 Promotes growth and differentiation of B cells and eosinophils Promotes class switching to IgA Th2 cells Interleukin-6 Stimulates fever Causes increased production of acute phase proteins by liver Macrophages Interleukin-8 Stimulates chemotaxis by neutrophils to sites of infection Macrophages Interleukin-10 Decreases inflammatory response by inhibiting macrophages and dendritic cells Decreases expression of MHC molecules and Th1 cytokines Regulatory T-cells Interleukin-12 Promotes differentiation of T-cells into Th1 cells Activates killing by NK cells Macrophages Tumor necrosis factor-α Alters vascular endothelium to promote leakage Recruits diverse white blood cells to site of release Induce fever Macrophages Interferon-α/β Activates antiviral defense system of cells Down regulates protein synthesis Upregulates MHC expression for easy recognition of infected cells All cells Interferon-γ Activates macrophages to kill ingested organisms Promotes granuloma formation Increases MHC and antigen presentation by all cells Increases killing by NK cells Th1 cells Effector Mechanisms Macrophage and neutrophil killing depends upon login to view 6 more bullets NK and cytotoxic CD8+ T-cell killing depends upon three mechanisms including login to view 5 more bullets Notably NK cells are inhibited by MHC complexes on the surface of cells